Abstract: The application of FDM3D printing technology in investment casting of a turbine blade was studied. The gating systems of side injection, top injection and bottom injection were designed. The best casting scheme was selected using the AnyCasting software analysis. Qualified castings were prepared using additive manufacturing technology and investment casting technology. The results show that AnyCasting software can accurately predict the defects of investment casting;investment casting process can well combine 3D printing technology, and can obtain excellent castings. The casting defects caused by the complicated manufacturing process of the turbine blade mold are solved.